ea0034p371 | Steroids | SFEBES2014
Larner Dean
, Morgan Stuart
, Gathercole Laura
, Nasiri Maryam
, Guest Philip
, Chapman Matthew
, Tomlinson Jeremy
, Stewart Paul
, Lavery Gareth
Non-alcoholic fatty liver disease (NAFLD) is characterised by intra-hepatocyte lipid accumulation. Simple steatosis, which is a reversible condition, can progress to non-alcoholic steatohepatitis (NASH), cirrhosis and eventually hepatocellular carcinoma. The aetiology of NAFLD is not fully understood and it is suggested that glucocorticoid reactivation through the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme may promote hepatic lipid accu...